Spectrophotometric Determination of Poorly Water Soluble Drug Terconazole Using Hydrotropic Solubilization Technique
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Spectrophotometric Estimation of Fluvoxamine Maleate in Tablets Using Hydrotropic Agent
Several techniques are used to increase the aqueous solubilities of poorly water soluble drugs. Hydrotropic solubilization technique is one of them. In the present investigation hydrotropic solution of Urea (10M) has been used as a solubilizing agent to solubilize poorly water soluble drug. Fluvoxamine maleate shows maximum absorbance at 271 nm. Beer’s law was obeyed in the concentration range ...
متن کاملFormulation and Evaluation of Aceclofenac Injection Made by Mixed Hydrotropic Solubilization Technique
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic and anti-inflammatory activities. It is practically insoluble in water. The effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. The enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...
متن کاملFormulation and Evaluation of Aceclofenac Injection Made by Mixed Hydrotropic Solubilization Technique
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic and anti-inflammatory activities. It is practically insoluble in water. The effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. The enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...
متن کاملQuantitative Spectrophotometric Determination of Ornidazole Tablet Formulations Using Ibuprofen Sodium as Hydrotropic Solubilizing Agent
Various techniques are employed to enhance the aqueous solubility of poorly watersoluble drugs and hydrotropic solubilization is one of them. In the present investigation, hydrotropic solution of ibuprofen sodium (0.5M) was employed as solubilizing agent to solubilize the poorly water-soluble drug, ornidazole from fine power of its tablets for spectrophotometric determination. Ornidazole shows ...
متن کاملNew Spectrophotometric Estimation of Ornidazole Tablets Employing Urea as a Hydrotropic Solubilizing Additive
Quantitative spectrophotometric analysis of poorly water-soluble drugs involves use of various organic solvents. Major drawbacks of organic solvents include high cost, volatility and toxicity. Safety of analyzer is affected by toxicity of the solvent used. In the present investigation the use of organic solvent has been avoided, making the method environmentally friendly. Urea has demonstrated ...
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